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results suggest that histone modifications in the promoter region of miR (zeige MLXIP Proteine)-500a may be responsible for the increased expression of miR (zeige MLXIP Proteine)-500a in Hepatocellular carcinoma (HCC (zeige FAM126A Proteine)), which promotes cancer progression by targeting BID, indicating that miR (zeige MLXIP Proteine)-500a may be a potential prognostic predictor and therapeutic target for HCC (zeige FAM126A Proteine) patients.
The caspase-8 (zeige CASP8 Proteine)/Bid/cytochrome c (zeige CYCS Proteine) axis links signals from death receptors to mitochondrial reactive oxygen species production.
administration of SMAC (zeige DIABLO Proteine) or BH3 mimetics following short-term paclitaxel treatment could be an effective therapeutic strategy for TNBC, while only BH3-mimetics could effectively overcome long-term paclitaxel resistance
caspase-10 (zeige CASP10 Proteine) was dispensable for enhancement of cisplatin/LA-12 and TRAIL combination-induced cell death and stimulation of Bid cleavage
an oligomeric arrangement of Bid, Bax (zeige BAX Proteine), and possibly other members of the Bcl-2 (zeige BCL2 Proteine) family of proteins that form a self-propagating network that permeabilizes the outer-mitochondrial membrane.
Combined therapy with Seliciclib((R)) and Belinostat((R)) results in eradication of non-small cell lung cancer via apoptosis induction and BID activation.
Results from genome-wide DNA methylation, functional network analysis and pyrosequencing, show selective CpG sites (NOS1AP, BID, and GABRB1) differentially methylated in smokers and chronic obstructive pulmonary disease patients compared to nonsmokers.
The adenovirus-mediated truncated Bid overexpression induced by the Cre/LoxP system can effectively eliminate CD133+ ovarian cancer stem cells, representing a novel therapeutic strategy for the treatment of ovarian cancer.
MiR (zeige MLXIP Proteine)-20a-directed regulation of BID in colorectal cancer.
the results establish that cleavage by caspase 8 (zeige CASP8 Proteine) and the subsequent association with the outer mitochondrial membrane are two critical events that activate Bid during death receptor-mediated apoptosis.
we show that BID is an important regulator downstream of FAS (zeige FAS Proteine) in mouse neutrophils. Loss of BID significantly delays FASL (zeige FASL Proteine)-cell death and partially counteracts the switch from apoptosis to necroptosis when caspases are blocked.
Study exposes BID as the molecular link between the previously separated pathways of oxidative stress signaling by merging the death pathways of ferroptosis and oxytosis at the level of mitochondria, i.e. the crucial point of decision for neuronal function and survival.
Cleaved Bid did not permeabilize the membrane, but lowered the membrane breakthrough force.
toxic reactive oxygen species levels in Mll5(-/-) mice are critically dependent on type 1 interferon (zeige IFNA Proteine) (IFN-1) signaling, which triggers mitochondrial accumulation of full-length Bid.
In the present study, we identified the proapoptotic Bcl-2 (zeige BCL2 Proteine) family protein Bid as a positive regulator of mutant SOD1 (zeige SOD1 Proteine)-induced TLR-nuclear factor-kappaB (NF-kappaB (zeige NFKB1 Proteine)) signaling in microglia.
ATM (zeige ATM Proteine)-BID-MTCH2 (zeige MTCH2 Proteine) pathway that we have identified plays a critical role in the DDR (zeige DDR1 Proteine) via regulation of mitochondrial metabolism.
DRP1 (zeige CRMP1 Proteine)-dependent apoptotic mitochondrial fission occurs independently of BAX (zeige BAX Proteine), BAK (zeige BAK1 Proteine) and APAF1 (zeige APAF1 Proteine) to amplify cell death by BID and oxidative stress.
A phosphorylation-deficient mutant of BID, MTCH2 (zeige MTCH2 Proteine)'s ligand, induces an increase in OXPHOS, but with higher ROS (zeige ROS1 Proteine) and reduced ATP levels than Mtch2 (zeige MTCH2 Proteine) loss, and is associated with hypersensitivity to irradiation.
Motifs of VDAC2 (zeige VDAC2 Proteine) required for mitochondrial Bak (zeige BAK1 Proteine) import and tBid-induced apoptosis.
BID protein suppresses p38 (zeige CRK Proteine) activity and induce malignant cell transformation of hepatocytes.
Stage-specific expression of TNFalpha (zeige TNF Proteine) regulates bad/bid-mediated apoptosis and RIP1 (zeige RALBP1 Proteine)/ROS (zeige ROS1 Proteine)-mediated secondary necrosis in Birnavirus-infected fish cells.
Bid and Bax (zeige BAX Proteine) are signal transduction factors in granulosa cells and play proapoptotic roles.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (zeige CASP3 Proteine)-dependent Proteolysis of JNK1 (zeige MAPK8 Proteine)-2 and Bid.
tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BID and Caspases-2 and -8
Here, we identified and characterized the Xenopus homologs of caspase-10 (zeige CASP10 Proteine) (xCaspase-10beta), a novel initiator caspase (zeige CASP3 Proteine), and Bid (xBid), a BH3-only (zeige BBC3 Proteine) molecule of the Bcl-2 (zeige BCL2 Proteine) family involved in both the extrinsic and intrinsic pathways.
diubiquitylation is a specific feature of xBid.
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8)\; CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
BH3-interacting domain death agonist
, BID isoform ES(1b)
, BID isoform L(2)
, BID isoform Si6
, Human BID coding sequence
, apoptic death agonist
, desmocollin type 4
, p22 BID
, apoptotic death agonist BID
, BH3 interacting domain death agonist