PPP1R10 Antikörper (AA 605-716)

Produktnummer ABIN968349

Produktdetails anti-PPP1R10 Antikörper

Target: PPP1R10 (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 10 (PPP1R10))

Bindungsspezifität: AA 605-716

Reaktivität: Human, Ratte, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PPP1R10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat PNUTS aa. 605-716

Klon: 47-PNUTS

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-PPP1R10 Antikörper (ABIN968349)

Allen, Kwon, Nairn, Greengard: "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit." in: The Journal of biological chemistry, Vol. 273, Issue 7, pp. 4089-95, (1998) (PubMed).

Details zu PPP1R10

Target: PPP1R10 (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 10 (PPP1R10))

Andere Bezeichnung: PNUTS (PPP1R10 Produkte)

Synonyme: CAT53 antikoerper, FB19 antikoerper, PNUTS antikoerper, PP1R10 antikoerper, R111 antikoerper, p99 antikoerper, Fb19 antikoerper, Pnuts antikoerper, 2610025H06Rik antikoerper, Cat53 antikoerper, D17Ertd808e antikoerper, CHUNP6885 antikoerper, fe15d12 antikoerper, fk54b08 antikoerper, ppp1r10l antikoerper, wu:fe15d12 antikoerper, wu:fk54b08 antikoerper, protein phosphatase 1 regulatory subunit 10 antikoerper, protein phosphatase 1, regulatory subunit 10 antikoerper, protein phosphatase 1 regulatory subunit 10 S homeolog antikoerper, PPP1R10 antikoerper, Ppp1r10 antikoerper, ppp1r10.S antikoerper, ppp1r10 antikoerper

Hintergrund: Many aspects of cellular physiology are influenced by the serine/threonine protein phosphatase1 (PP1). It is a highly conserved eukaryotic protein that reverses the action of protein kinases. PP1 is key to such processes as cell division, neuronal metabolism, and protein synthesis. It consists of a catalytic subunit, with a broad substrate specificity, whose action is directed by its association with a family of regulatory proteins including inhibitor-1, inhibitor-2, and NIPP-1. In response to extracellular stimuli, these proteins interact with PP1 and inhibit its catalytic activity. Other regulatory proteins are referred to as targeting subunits because they direct PP1 to specific subcellular locations and modulate its activity. In the cell nucleus, PP1 has been implicated in a variety of processes. Nuclear PP1 exists in high MW complexes with other proteins including NIPP-1. PNUTS (phosphatase 1 nuclear targeting subunit) is a ubiquitously expressed nuclear protein that forms a stable complex with PP1 and is thought to modulate its catalytic activity. Thus, PNUTS is a specific regulatory protein that directs the nuclear function of PP1.

Molekulargewicht: 110 kDa

Pathways: Protein targeting to Nucleus