HSD11B1 Antikörper (AA 131-145)

Produktnummer ABIN966304

Produktdetails anti-HSD11B1 Antikörper

Target: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Bindungsspezifität: AA 131-145

Reaktivität: Human, Maus, Ratte

Wirt: Bitte anfragen

Klonalität: Polyklonal

Konjugat: Dieser HSD11B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Immunogen: A synthetic peptide corresponding to a sequence at the middle region of human HSD11B1 (131-145 aa), different from the mouse sequence by two amino acids.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Lagerung: -20 °C

Details zu HSD11B1

Target: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Andere Bezeichnung: HSD11B1 (HSD11B1 Produkte)

Synonyme: 11-DH antikoerper, 11-beta-HSD1 antikoerper, CORTRD2 antikoerper, HDL antikoerper, HSD11 antikoerper, HSD11B antikoerper, HSD11L antikoerper, SDR26C1 antikoerper, hsd11 antikoerper, hsd11b antikoerper, LRRGT00065 antikoerper, hydroxysteroid 11-beta dehydrogenase 1 antikoerper, hydroxysteroid (11-beta) dehydrogenase 1b antikoerper, hydroxysteroid (11-beta) dehydrogenase 1 L homeolog antikoerper, HSD11B1 antikoerper, HSD11B1b antikoerper, hsd11b1.L antikoerper, Hsd11b1 antikoerper

Hintergrund: 11-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors.It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcersTannin et al. (1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al. (2000) mapped the HSD11B1 gene to 1q32-q41.

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process