DDC Antikörper (C-Term)

Produktnummer ABIN965981

Produktdetails anti-DDC Antikörper

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDC Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human DDC (Netrin receptor DCC precursor) (Tumor suppressor protein DCC)

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu DDC

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Andere Bezeichnung: DDC (DDC Produkte)

Synonyme: AADC antikoerper, wu:fa56d05 antikoerper, wu:fd59h03 antikoerper, wu:fk20h01 antikoerper, zgc:65801 antikoerper, zgc:76929 antikoerper, Ddc antikoerper, DdcDv antikoerper, Dvir\\GJ17995 antikoerper, GJ17995 antikoerper, dvir_GLEANR_2561 antikoerper, Aadc antikoerper, 5-HT antikoerper, CG10697 antikoerper, DDC antikoerper, DdcDm antikoerper, Dmel\\CG10697 antikoerper, ddc antikoerper, fDDC antikoerper, l(2)37Bl antikoerper, l(2)37Ch antikoerper, l(2)k02104 antikoerper, dopa decarboxylase antikoerper, Dopa-decarboxylase antikoerper, dopa decarboxylase (aromatic L-amino acid decarboxylase) antikoerper, Dopa decarboxylase antikoerper, dopa decarboxylase L homeolog antikoerper, DDC antikoerper, ddc antikoerper, Ddc antikoerper, Dvir\Ddc antikoerper, ddc.L antikoerper

Hintergrund: DDC (Netrin receptor DCC) (Tumor suppressor protein DCC) is a receptor for netrin required for axon guidance. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. The protein implicated as a tumor suppressor gene. It interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D (By similarity). Colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression. Inactivation of DCC due to allelic deletion and/or point mutations may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas.

Pathways: Dopaminergic Neurogenesis