IKK alpha Antikörper (AA 500-590)

Produktnummer ABIN965896

Dieser Maus Monoklonal Antikörper detektiert spezifisch IKK alpha in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für IKK alpha Antikörper (AA 500-590) (ABIN965896)

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IKK alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 7C10B6-1A10A10

Produktdetails anti-IKK alpha Antikörper

Bindungsspezifität: AA 500-590

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of CHUK (aa500-590) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-IKK alpha Antikörper (ABIN965896)

Park, Krishnan, OMalley, Yamamoto, Gaynor: "Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation." in: Molecular cell, Vol. 18, Issue 1, pp. 71-82, (2005) (PubMed).

Prajapati, Verma, Yamamoto, Kwak, Gaynor: "Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1739-46, (2004) (PubMed).

Details zu IKK alpha

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Andere Bezeichnung: CHUK

Hintergrund: CHUK: conserved helix-loop-helix ubiquitous kinase. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
Synonyms: IKK1, IKKA, IKBKA

Gen-ID: 1147

Pathways: PI3K-Akt Signalweg, NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine