CD86 Antikörper

Produktnummer ABIN965821

Produktdetails anti-CD86 Antikörper

Target: CD86

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD86 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human CD86 expressed in E. Coli.

Klon: 1B3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-CD86 Antikörper (ABIN965821)

Kim, Lee, Kim, Jee, Kim, Park, Min, Park: "Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions." in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Vol. 39, Issue 12, pp. 1852-6, (2010) (PubMed).

Carreño, Pacheco, Gutierrez, Jacobelli, Kalergis: "Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells." in: Immunology, Vol. 128, Issue 3, pp. 334-41, (2010) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Details zu CD86

Target: CD86

Andere Bezeichnung: CD86 (CD86 Produkte)

Synonyme: B7-2 antikoerper, B7.2 antikoerper, B70 antikoerper, CD28LG2 antikoerper, LAB72 antikoerper, B7 antikoerper, CLS1 antikoerper, Cd28l2 antikoerper, ETC-1 antikoerper, Ly-58 antikoerper, Ly58 antikoerper, MB7 antikoerper, MB7-2 antikoerper, TS/A-2 antikoerper, CD86 molecule antikoerper, CD86 antigen antikoerper, integrin subunit alpha 2b antikoerper, CD86 antikoerper, Cd86 antikoerper, Itga2b antikoerper

Hintergrund: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
Tissue specificity: Expressed by activated B-lymphocytes and monocytes.
Synonyms: B70, B7-2, LAB72, CD28LG2, MGC34413, CD86

Molekulargewicht: 52kDa

Gen-ID: 942

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation