C6orf150 Antikörper (Middle Region)

Produktnummer ABIN950947

Produktdetails anti-C6orf150 Antikörper

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Bindungsspezifität: AA 273-303, Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C6orf150 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes Human C6orf150 (CF150). Other species not tested.

Aufreinigung: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 273-303 amino acids from the Central region of human CF150

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu C6orf150

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Andere Bezeichnung: C6orf150 (C6orf150 Produkte)

Synonyme: C6orf150 antikoerper, cGAS antikoerper, h-cGAS antikoerper, Mab-21 domain containing 1 antikoerper, cyclic GMP-AMP synthase antikoerper, MB21D1 antikoerper, CGAS antikoerper

Hintergrund: Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Cellular Location: Cytoplasm, cytosol. Tissue Location: Expressed in the monocytic cell line THP1.Synonyms: Uncharacterized protein C6orf150

Molekulargewicht: 58814 Da

Gen-ID: 115004

NCBI Accession: NP_612450

Pathways: Activation of Innate immune Response