Calcineurin B Antikörper

Produktnummer ABIN933160

Produktdetails anti-Calcineurin B Antikörper

Target: Calcineurin B (CAN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Calcineurin B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Sterilität: Filtered

Immunogen: Calcineurin B antibody was raised in mouse using E. coli-derived recombinant human calcineurin B as the immunogen.

Klon: 323417

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 0.5 µg/mL
Optimal conditions should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with sterile PBS.

Konzentration: Lot specific

Buffer: Lyophilized from a 0.2 µm filtered solution in PBS with 5 % trehalose.

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.

Details zu Calcineurin B

Target: Calcineurin B (CAN)

Andere Bezeichnung: Calcineurin B (CAN Produkte)

Synonyme: PPP3RL antikoerper, BcDNA:RH11383 antikoerper, CG4209 antikoerper, CNB antikoerper, Can antikoerper, CnB antikoerper, Dmel\\CG4209 antikoerper, canB-4F antikoerper, dCnB1 antikoerper, Cnb antikoerper, Cblp antikoerper, CaNB2 antikoerper, protein phosphatase 3 regulatory subunit B, beta antikoerper, Calcineurin B antikoerper, calcineurin B antikoerper, protein phosphatase 3, regulatory subunit B, beta antikoerper, protein phosphatase 3 regulatory subunit B, alpha antikoerper, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) antikoerper, PPP3R2 antikoerper, CanB antikoerper, Cnb antikoerper, Ppp3r2 antikoerper, PPP3R1 antikoerper

Hintergrund: Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and formerly known as protein phosphatase 2B (PP2B). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates NFATc (Nuclear Factor of Activated T cell, cytoplasmic), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes ciclosporin, pimecrolimus and tacrolimus. Synonyms: Monoclonal Calcineurin B antibody, Anti-Calcineurin B antibody.

Pathways: Cellular Glucan Metabolic Process, VEGF Signaling