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HVEM Antikörper (AA 51-150) (Alexa Fluor 488)

TNFRSF14 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 488
Produktnummer ABIN918128
  • Target Alle HVEM (TNFRSF14) Antikörper anzeigen
    HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
    Bindungsspezifität
    • 14
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-150
    Reaktivität
    • 66
    • 10
    • 1
    • 1
    Human
    Wirt
    • 52
    • 17
    • 3
    • 1
    • 1
    • 1
    Kaninchen
    Klonalität
    • 52
    • 21
    • 2
    Polyklonal
    Konjugat
    • 38
    • 8
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HVEM Antikörper ist konjugiert mit Alexa Fluor 488
    Applikation
    • 47
    • 35
    • 28
    • 24
    • 12
    • 12
    • 9
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human
    Homologie
    Dog,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TNFRSF14
    Isotyp
    IgG
    Top Product
    Discover our top product TNFRSF14 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
    Andere Bezeichnung
    Tnfrsf14/Hvem (TNFRSF14 Produkte)
    Synonyme
    ATAR antikoerper, CD270 antikoerper, HVEA antikoerper, HVEM antikoerper, LIGHTR antikoerper, TR2 antikoerper, Atar antikoerper, HveA antikoerper, Hvem antikoerper, Tnfrs14 antikoerper, TNF receptor superfamily member 14 antikoerper, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) antikoerper, Tnfrsf14 antikoerper, TNFRSF14 antikoerper
    Substanzklasse
    Viral Protein
    Hintergrund

    Synonyms: Tumor necrosis factor receptor superfamily member 14, HVEML, ATAR, CD258, CD258 antigen, CD40 like protein precursor, Herpesvirus entry mediator A, Herpesvirus entry mediator, Herpesvirus entry mediator ligand, HVEA, HVEM, HVEM L, HVEML, LIGHT, LIGHTR, TNFSF 14, TR2, Tumor necrosis factor receptor like gene2, TNR14_HUMAN.

    Background: TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.

    Gen-ID
    8764
    Pathways
    Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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