p107 Antikörper (AA 751-850) (Alexa Fluor 488)
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- Target Alle p107 (RBL1) Antikörper anzeigen
- p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
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Bindungsspezifität
- AA 751-850
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser p107 Antikörper ist konjugiert mit Alexa Fluor 488
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Applikation
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human p107/RBL1
- Isotyp
- IgG
- Top Product
- Discover our top product RBL1 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
- Andere Bezeichnung
- p107 (RBL1 Produkte)
- Synonyme
- p107 antikoerper, prb1 antikoerper, fj58e06 antikoerper, wu:fj58e06 antikoerper, CP107 antikoerper, PRB1 antikoerper, AW547426 antikoerper, retinoblastoma-like 1 L homeolog antikoerper, RB transcriptional corepressor like 1 antikoerper, retinoblastoma-like 1 (p107) antikoerper, retinoblastoma-like 1 antikoerper, rbl1.L antikoerper, RBL1 antikoerper, rbl1 antikoerper, Rbl1 antikoerper
- Hintergrund
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Synonyms: 107 kDa retinoblastoma-associated protein, Cellular protein 107, Cellular protein p107, CP107, MGC40006, p107, PRB1, RBL1, RBL1_HUMAN, Retinoblastoma like protein 1, retinoblastoma-like 1 p107, Retinoblastoma-like protein 1.
Background: p107 is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
- Gen-ID
- 5933
- Pathways
- Zellzyklus, Mitotic G1-G1/S Phases
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