MAP2K5 Antikörper (AA 251-350) (Alexa Fluor 647)
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- Target Alle MAP2K5 Antikörper anzeigen
- MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))
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Bindungsspezifität
- AA 251-350
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MAP2K5 Antikörper ist konjugiert mit Alexa Fluor 647
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Applikation
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Maus, Ratte
- Homologie
- Dog,Cow,Pig,Horse,Chicken,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human MEK5
- Isotyp
- IgG
- Top Product
- Discover our top product MAP2K5 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))
- Andere Bezeichnung
- MEK5 (MAP2K5 Produkte)
- Synonyme
- Mek5 antikoerper, HsT17454 antikoerper, MAPKK5 antikoerper, MEK5 antikoerper, PRKMK5 antikoerper, AI324775 antikoerper, AI428457 antikoerper, Mapkk5 antikoerper, Prkmk5 antikoerper, fb73f02 antikoerper, wu:fb73f02 antikoerper, zgc:172137 antikoerper, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 antikoerper, ATMAP2K_ALPHA antikoerper, ATMEK5 antikoerper, ATMKK5 antikoerper, MAP KINASE KINASE 5 antikoerper, MAP kinase kinase 5 antikoerper, MAP2K_A antikoerper, mitogen activated protein kinase kinase 5 antikoerper, mitogen-activated protein kinase kinase 5 antikoerper, mitogen-activated protein kinase kinase 5 L homeolog antikoerper, MAP kinase kinase 5 antikoerper, Map2k5 antikoerper, MAP2K5 antikoerper, map2k5 antikoerper, map2k5.L antikoerper, MKK5 antikoerper
- Hintergrund
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Synonyms: MEK5, MAPKK5, Dual specificity mitogen-activated protein kinase kinase 5, MAPK/ERK kinase 5, MEK 5, MAP2K5, MAP kinase kinase 5
Background: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
- Gen-ID
- 5607
- UniProt
- Q13163
- Pathways
- MAPK Signalweg, Neurotrophin Signalübertragung
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