LCAT Antikörper (AA 151-250) (Alexa Fluor 488)

Produktnummer ABIN904638

Produktdetails anti-LCAT Antikörper (Alexa Fluor 488)

Target: LCAT (Lecithin-Cholesterol Acyltransferase (LCAT))

Bindungsspezifität: AA 151-250

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LCAT Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LCAT

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu LCAT

Target: LCAT (Lecithin-Cholesterol Acyltransferase (LCAT))

Andere Bezeichnung: Lcat (LCAT Produkte)

Synonyme: AI046659 antikoerper, D8Wsu61e antikoerper, MGC82035 antikoerper, lcat antikoerper, MGC88964 antikoerper, LCAT antikoerper, lecithin-cholesterol acyltransferase antikoerper, lecithin cholesterol acyltransferase antikoerper, lecithin-cholesterol acyltransferase L homeolog antikoerper, solute carrier family 12 member 4 antikoerper, fragile site, aphidicolin type, common, fra(13)(q13.2) antikoerper, LCAT antikoerper, Lcat antikoerper, lcat.L antikoerper, lcat antikoerper, SLC12A4 antikoerper, FRA13A antikoerper

Hintergrund:

Synonyms: Phosphatidylcholine-sterol acyltransferase, Lecithin-cholesterol acyltransferase, Phospholipid-cholesterol acyltransferase, LCAT

Background: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms.

Gen-ID: 3931

UniProt: P04180

Pathways: Lipid Metabolism