Dystroglycan Antikörper (AA 451-550) (Alexa Fluor 350)

Produktnummer ABIN893408

Produktdetails anti-Dystroglycan Antikörper (Alexa Fluor 350)

Target: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Bindungsspezifität: AA 451-550

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Dystroglycan Antikörper ist konjugiert mit Alexa Fluor 350

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DAG1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Dystroglycan

Target: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Andere Bezeichnung: Alpha Dystroglycan (DAG1 Produkte)

Synonyme: LOC398500 antikoerper, dag1 antikoerper, MGC53537 antikoerper, 156DAG antikoerper, A3a antikoerper, AGRNR antikoerper, DAG antikoerper, MDDGC7 antikoerper, MDDGC9 antikoerper, DAG1 antikoerper, RAB7 antikoerper, dg antikoerper, a3a antikoerper, dag antikoerper, agrnr antikoerper, 156dag antikoerper, D9Wsu13e antikoerper, DG antikoerper, Dp427 antikoerper, Dp71 antikoerper, CG18250 antikoerper, CT41273 antikoerper, DmDG antikoerper, Dmel\\CG18250 antikoerper, atu antikoerper, dgn antikoerper, dys antikoerper, GB14967 antikoerper, APOJ antikoerper, CLI antikoerper, RATTRPM2B antikoerper, SGP-2 antikoerper, SGP2 antikoerper, SP-40 antikoerper, SP40 antikoerper, TRPM-2 antikoerper, TRPM2B antikoerper, Trpm2 antikoerper, Trpmb antikoerper, Ala-1 antikoerper, H9/25 antikoerper, Ly-27 antikoerper, Ly-6 antikoerper, Ly27 antikoerper, wu:fb83d06 antikoerper, wu:fi25f06 antikoerper, wu:fi37b08 antikoerper, zgc:109786 antikoerper, DystroGlycaN antikoerper, dystroglycan 1 L homeolog antikoerper, dystroglycan 1 antikoerper, dystroglycan 1 S homeolog antikoerper, Dystroglycan antikoerper, dystroglycan antikoerper, clusterin antikoerper, lymphocyte antigen 6 complex antikoerper, dgn-1 antikoerper, dag1.L antikoerper, dgn-2 antikoerper, dgn-3 antikoerper, DAG1 antikoerper, dag1.S antikoerper, Dag1 antikoerper, dag1 antikoerper, Dg antikoerper, LOC408826 antikoerper, Clu antikoerper, Ly6 antikoerper

Hintergrund:

Synonyms: AGRNR, Alpha-DG, Beta-DG, Beta-dystroglycan, beta Dystroglycan, DAG, Dag1, DAG1_HUMAN, Dystroglycan 1 dystrophin-associated glycoprotein 1, Dystroglycan, Dystrophin-associated glycoprotein 1, 156DAG, A3a, Dystrophin-associated glycoprotein 1.

Background: Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010]

Gen-ID: 1605

UniProt: Q14118

Pathways: Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus