CYP2R1 Antikörper (AA 251-350) (Alexa Fluor 647)

Produktnummer ABIN893211

Produktdetails anti-CYP2R1 Antikörper (Alexa Fluor 647)

Target: CYP2R1 (Cytochrome P450, Family 2, Subfamily R, Polypeptide 1 (CYP2R1))

Bindungsspezifität: AA 251-350

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYP2R1 Antikörper ist konjugiert mit Alexa Fluor 647

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CYP2R1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CYP2R1

Target: CYP2R1 (Cytochrome P450, Family 2, Subfamily R, Polypeptide 1 (CYP2R1))

Andere Bezeichnung: CYP2R1 (CYP2R1 Produkte)

Synonyme: cytochrome P450 family 2 subfamily R member 1 antikoerper, cytochrome P450, family 2, subfamily R, polypeptide 1 antikoerper, cytochrome P450, family 2, subfamily r, polypeptide 1 antikoerper, CYP2R1 antikoerper, cyp2r1 antikoerper, Cyp2r1 antikoerper

Hintergrund:

Synonyms: Cytochrome P450 2R1, Cytochrome P450 family 2 R1, Cytochrome P450 family 2 subfamily R polypeptide 1, EC 1.14.13.15, MGC4663, Vitamin D 25 hydroxylase.

Background: CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor.Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency, also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity and low levels of 25-hydroxyvitamin D.

Gen-ID: 120227

Pathways: Metabolism of Steroid Hormones and Vitamin D