BNIP3L/NIX Antikörper (AA 51-150) (Alexa Fluor 488)

Produktnummer ABIN885334

Produktdetails anti-BNIP3L/NIX Antikörper (Alexa Fluor 488)

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Bindungsspezifität: AA 51-150

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BNIP3L/NIX Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BNIP3L

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu BNIP3L/NIX

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Andere Bezeichnung: BNIP3L (BNIP3L Produkte)

Synonyme: BNIP3a antikoerper, NIX antikoerper, NIP3 antikoerper, Nix antikoerper, Nip3 antikoerper, C86132 antikoerper, D14Ertd719e antikoerper, Nip3L antikoerper, bnip3l antikoerper, nip3 antikoerper, zgc:110478 antikoerper, bnip3l2 antikoerper, wu:fb52b03 antikoerper, wu:fc02h04 antikoerper, BCL2 interacting protein 3 like antikoerper, BCL2 interacting protein 3 antikoerper, BCL2/adenovirus E1B interacting protein 3 antikoerper, BCL2/adenovirus E1B interacting protein 3-like antikoerper, BCL2/adenovirus E1B interacting protein 3-like b antikoerper, BCL2/adenovirus E1B interacting protein 3-like a antikoerper, BNIP3L antikoerper, BNIP3 antikoerper, Bnip3l antikoerper, Bnip3 antikoerper, bnip3lb antikoerper, bnip3la antikoerper

Hintergrund:

Synonyms: NIX, BNIP3a, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like, Adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, NIP3-like protein X, NIP3L, BNIP3L, BNIP3H

Background: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.

Gen-ID: 665

UniProt: O60238

Pathways: Autophagie