ATG3 Antikörper (pTyr18) (Alexa Fluor 488)

Produktnummer ABIN879132

Produktdetails anti-ATG3 Antikörper (Alexa Fluor 488)

Target: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Bindungsspezifität: pTyr18

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG3 Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human ATG3 around the phosphorylation site of Tyr18

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ATG3

Target: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Andere Bezeichnung: ATG3 (ATG3 Produkte)

Synonyme: atg3 antikoerper, im:6910145 antikoerper, wu:fb15g12 antikoerper, zgc:64156 antikoerper, APG3 antikoerper, APG3-LIKE antikoerper, APG3L antikoerper, PC3-96 antikoerper, 2610016C12Rik antikoerper, Apg3l antikoerper, Atg3l antikoerper, PIG-1 antikoerper, Pig1 antikoerper, ATATG3 antikoerper, K11J9.1 antikoerper, K11J9_1 antikoerper, autophagy related 3 antikoerper, autophagy 3 (APG3) antikoerper, similar to S. cerevisiae ATG3 (YNR007C) part of ubiquitin-like system that mediates Atg8-phosphatidylethanolamine conjugation required for protein-vacuolar targeting and autophagy antikoerper, atg3 antikoerper, ATG3 antikoerper, Atg3 antikoerper

Hintergrund:

Synonyms: 2610016C12Rik, Apg 3, APG3, APG3 autophagy 3 like, APG3 like, APG3-like, APG3L, Apg3p, ATG 3, ATG3, ATG3 autophagy related 3 homolog, ATG3 autophagy related 3 homolog S. cerevisiae, ATG3_HUMAN, Autophagy Apg3p/Aut1p like, Autophagy related protein 3, Autophagy-related protein 3, DKFZp564M1178, FLJ22125, hApg3, MGC15201, OTTHUMP00000214547, OTTHUMP00000214548, PC3 96, Protein PC3-96, Ubiquitin-like-conjugating enzyme ATG3.

Background: E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.

Gen-ID: 64422

Pathways: Autophagie