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TSC1 Antikörper (pSer505) (AbBy Fluor® 555)

TSC1 Reaktivität: Human, Maus, Schaf WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 555
Produktnummer ABIN876421
  • Target Alle TSC1 Antikörper anzeigen
    TSC1 (Tuberous Sclerosis 1 (TSC1))
    Bindungsspezifität
    • 23
    • 16
    • 16
    • 16
    • 15
    • 15
    • 13
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer505
    Reaktivität
    • 187
    • 138
    • 53
    • 24
    • 17
    • 2
    • 1
    • 1
    Human, Maus, Schaf
    Wirt
    • 301
    • 16
    • 1
    • 1
    Kaninchen
    Klonalität
    • 303
    • 16
    Polyklonal
    Konjugat
    • 114
    • 37
    • 36
    • 36
    • 32
    • 32
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    Dieser TSC1 Antikörper ist konjugiert mit AbBy Fluor® 555
    Applikation
    • 230
    • 208
    • 91
    • 28
    • 25
    • 25
    • 16
    • 14
    • 9
    • 7
    • 6
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Schaf
    Homologie
    Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human TSC1 around the phosphorylation site of Ser505 [FD(p-S)PF]
    Isotyp
    IgG
    Top Product
    Discover our top product TSC1 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    TSC1 (Tuberous Sclerosis 1 (TSC1))
    Andere Bezeichnung
    TSC1 (TSC1 Produkte)
    Synonyme
    LAM antikoerper, TSC antikoerper, hamartin antikoerper, mKIAA0243 antikoerper, tsc1 antikoerper, wu:fc38b04 antikoerper, fa99f04 antikoerper, wu:fa99f04 antikoerper, zgc:63657 antikoerper, TSC complex subunit 1 antikoerper, tuberous sclerosis 1 antikoerper, TSC complex subunit 1b antikoerper, TSC complex subunit 1a antikoerper, TSC1 antikoerper, Tsc1 antikoerper, tsc1b antikoerper, tsc1 antikoerper, tsc1a antikoerper
    Hintergrund

    Synonyms: TSC1phospho S505, LAM, TSC1, Tuberous sclerosis 1 protein.

    Background: Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.

    Gen-ID
    7248
    Pathways
    RTK Signalweg, AMPK Signaling, Regulation of Cell Size, Tube Formation
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