DFFB Antikörper (AA 251-338)

Produktnummer ABIN872776

Produktdetails anti-DFFB Antikörper

Target: DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))

Bindungsspezifität: AA 251-338

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DFFB Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DFFB

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu DFFB

Target: DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))

Andere Bezeichnung: DFFB (DFFB Produkte)

Synonyme: CAD antikoerper, CPAN antikoerper, DFF-40 antikoerper, DFF2 antikoerper, DFF40 antikoerper, LOC100223514 antikoerper, 40kDa antikoerper, 5730477D02Rik antikoerper, Didff antikoerper, Cad antikoerper, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase antikoerper, DNA fragmentation factor subunit beta antikoerper, DNA fragmentation factor, beta polypeptide (caspase-activated DNase) antikoerper, DNA fragmentation factor, beta subunit antikoerper, CAD antikoerper, DFFB antikoerper, dffb antikoerper, LOC100223514 antikoerper, Dffb antikoerper

Hintergrund:

Synonyms: CAD, Caldesmon, Caspase activated deoxyribonuclease, Caspase activated DNase, Caspase activated nuclease, CDM, CPAN, Deoxyribonuclease III, caspase activated, DFF 40, DFF2, DFF40, Didff, DNA fragmentation factor 40 kDa subunit, DNA fragmentation factor subunit beta, DNA fragmentation factor, 40 Da, beta polypeptide caspase activated DNase, DNA fragmentation factor, 40 kD beta subunit, DNA fragmentation factor, 40 kD, beta polypeptide, DNA fragmentation factor, 40 kDa, beta polypeptide caspase activated DNase, DNA fragmentation factor, 40 kDa, beta polypeptide caspase-activated DNase, DNAation factor, beta subunit, DFFB_HUMAN.

Background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008].

Gen-ID: 1677

Pathways: Apoptose, Caspase Kaskade in der Apoptose