HDAC8 Antikörper (pSer39)

Produktnummer ABIN871411

Produktdetails anti-HDAC8 Antikörper

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Bindungsspezifität: pSer39

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC8 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Spezifität: The antibody detects endogenous level of HDAC8 only when phosphorylated at serine 39.

Aufreinigung: Affinity purified

Immunogen: Peptide sequence around phosphorylation site of pSer39 (R-A-S (p) -M-V) derived from Human HDAC8. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu HDAC8

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Andere Bezeichnung: HDAC8 (HDAC8 Produkte)

Synonyme: HD8 antikoerper, CDLS5 antikoerper, HDACL1 antikoerper, MRXS6 antikoerper, RPD3 antikoerper, WTS antikoerper, 2610007D20Rik antikoerper, RGD1562895 antikoerper, wu:fd19a02 antikoerper, zgc:66196 antikoerper, ATHDA8 antikoerper, HDA8 antikoerper, HISTONE DEACETYLASE 8 antikoerper, T27G7.14 antikoerper, T27G7_14 antikoerper, histone deacetylase 8 antikoerper, histone deacetylase 8 antikoerper, histone deacetylase 8 L homeolog antikoerper, CC1G_05302 antikoerper, hdac8 antikoerper, HDAC8 antikoerper, Hdac8 antikoerper, hdac8.L antikoerper, HDA08 antikoerper

Hintergrund: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC8 gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 42 kDa

Gen-ID: 558

NCBI Accession: NP_001159

UniProt: Q9BY41

Pathways: Cellular Glucan Metabolic Process