PTPRJ Antikörper (AA 865-970)
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- Target Alle PTPRJ Antikörper anzeigen
- PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))
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Bindungsspezifität
- AA 865-970
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PTPRJ Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Kreuzreaktivität
- Human, Maus
- Homologie
- Rat,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human PTPRJ
- Isotyp
- IgG
- Top Product
- Discover our top product PTPRJ Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))
- Andere Bezeichnung
- DEP1/PTPRJ (PTPRJ Produkte)
- Synonyme
- HAAP antikoerper, CD148 antikoerper, DEP1 antikoerper, HPTPeta antikoerper, R-PTP-ETA antikoerper, SCC1 antikoerper, AI450271 antikoerper, BET antikoerper, Byp antikoerper, DEP-1 antikoerper, PTPbeta2 antikoerper, Ptpb2 antikoerper, RPTPJ antikoerper, Scc-1 antikoerper, Scc1 antikoerper, PTPRJ antikoerper, acid phosphatase 1 antikoerper, protein tyrosine phosphatase, receptor type J antikoerper, protein tyrosine phosphatase, receptor type, J antikoerper, ACP1 antikoerper, PTPRJ antikoerper, Ptprj antikoerper, EUBREC_2762 antikoerper
- Hintergrund
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Synonyms: DEP1, SCC1, CD148, HPTPeta, R-PTP-ETA, Receptor-type tyrosine-protein phosphatase eta, Protein-tyrosine phosphatase eta, Density-enhanced phosphatase 1, DEP-1, HPTP eta, Protein-tyrosine phosphatase receptor type J, R-PTP-J, PTPRJ
Background: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration, through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation, through KDR dephosphorylation. Negative regulator of EGFR signaling pathway, through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
- Gen-ID
- 5795
- UniProt
- Q12913
- Pathways
- EGFR Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
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