Caspase 1 (p10) Antikörper (AA 320-404)

Produktnummer ABIN725780

Produktdetails anti-Caspase 1 (p10) Antikörper

Target: Caspase 1 (p10) (CASP-1 (p10))

Bindungsspezifität: AA 320-404

Reaktivität: Human, Maus, Ratte, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 1 (p10) Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Huhn, Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Caspase-1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Caspase 1 (p10) Antikörper (ABIN725780)

Daverey, Agrawal: "Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes." in: Neuroscience, Vol. 333, pp. 92-103, (2016) (PubMed).

Wang, Lei, Zhang, Zhao, Fang, Lai, Han, Xiao, Wang: "Xenobiotic Pregnane X Receptor (PXR) Regulates Innate Immunity via Activation of NLRP3 Inflammasome in Vascular Endothelial Cells." in: The Journal of biological chemistry, Vol. 289, Issue 43, pp. 30075-81, (2014) (PubMed).

Yao, Wigginton, Maass, Ma, Carlson, Wolf, Minei, Zang: "Estrogen-provided cardiac protection following burn trauma is mediated through a reduction in mitochondria-derived DAMPs." in: American journal of physiology. Heart and circulatory physiology, Vol. 306, Issue 6, pp. H882-94, (2014) (PubMed).

Hu, Kang, Chen, Mamuti, Wu, Yuan: "Drug-induced apoptosis of Echinococcus granulosus protoscoleces." in: Parasitology research, Vol. 109, Issue 2, pp. 453-9, (2011) (PubMed).

Details zu Caspase 1 (p10)

Target: Caspase 1 (p10) (CASP-1 (p10))

Andere Bezeichnung: Caspase-1 P10 (CASP-1 (p10) Produkte)

Hintergrund:

Synonyms: ICE, P45, IL1BC, Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme, CASP1, IL1BCE

Background: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Gen-ID: 834

UniProt: P29466