ID4 Antikörper (AA 61-160)

Produktnummer ABIN719696

Produktdetails anti-ID4 Antikörper

Target: ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))

Bindungsspezifität: AA 61-160

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ID4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ID4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu ID4

Target: ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))

Andere Bezeichnung: ID4 (ID4 Produkte)

Synonyme: Idb4 antikoerper, bHLHb27 antikoerper, cb547 antikoerper, fb77d04 antikoerper, sb:cb547 antikoerper, wu:fb77d04 antikoerper, zgc:123214 antikoerper, bhlhb27 antikoerper, id4 antikoerper, id4a antikoerper, idb4 antikoerper, IDB4 antikoerper, inhibitor of DNA binding 4 antikoerper, inhibitor of DNA binding 4, HLH protein antikoerper, inhibitor of DNA binding 4, HLH protein S homeolog antikoerper, Id4 antikoerper, id4 antikoerper, id4.S antikoerper, ID4 antikoerper

Hintergrund:

Synonyms: bHLHb27, Class B basic helix-loop-helix protein 27, DNA binding protein inhibitor ID 4, DNA binding protein inhibitor ID4, DNA-binding protein inhibitor ID-4, ID 4, Id4, ID4_HUMAN, IDB4, Inhibitor of DNA binding 4, Inhibitor of DNA binding 4 dominant negative helix loop helix protein.

Background: Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1 (13), Id2 (4), Id3 and Id4 (5). They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins (15). Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.

Gen-ID: 3400