E2F5 Antikörper

Produktnummer ABIN7464416

Produktdetails anti-E2F5 Antikörper

Target: E2F5

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser E2F5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Knockdown/Knockout validation was supported by references (PMID:36883841)

Kreuzreaktivität: Human, Maus

Aufreinigung: Purified by antigen-affinity chromatography.

Güteklasse: KO Validated

Immunogen: Recombinant protein encompassing a sequence within the center region of human E2F5. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:20000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: HA-human E2F5-transfected 293T cells , A549 , H1299 , HCT116 , mouse placenta , mouse leukocyte treated with CFA

Validation: KO/KD, Orthogonal, Overexpression

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu E2F5

Target: E2F5

Andere Bezeichnung: E2F transcription factor 5 (E2F5 Produkte)

Synonyme: AU024671 antikoerper, E2F-5 antikoerper, E2f-5 antikoerper, E2F4 antikoerper, cb735 antikoerper, zgc:111879 antikoerper, E2F transcription factor 5 antikoerper, E2f5 antikoerper, e2f5 antikoerper, E2F5 antikoerper

Hintergrund: E2F transcription factor 5 , E2F-5,The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq]

Molekulargewicht: 38 kDa

Gen-ID: 1875

UniProt: Q15329