B4GALT1 Antikörper

Produktnummer ABIN7490650

Produktdetails anti-B4GALT1 Antikörper

Target: B4GALT1 (UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1))

Fragment: Fc fragment

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser B4GALT1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Produktmerkmale: Rabbit/Human Fc chimeric IgG1

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cyt  1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Details zu B4GALT1

Target: B4GALT1 (UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1))

Andere Bezeichnung: B4GALT1 (B4GALT1 Produkte)

Synonyme: B4GAL-T1 antikoerper, CDG2D antikoerper, GGTB2 antikoerper, GT1 antikoerper, GTB antikoerper, beta4Gal-T1 antikoerper, B-1,4-GalT antikoerper, B-1,4-GalT1 antikoerper, GalT antikoerper, Ggtb antikoerper, Ggtb2 antikoerper, b4Gal-T1 antikoerper, beta-1,4-GalT antikoerper, beta-1,4-GalT1 antikoerper, beta-1,4-galactosyltransferase 1 antikoerper, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 antikoerper, B4GALT1 antikoerper, B4galt1 antikoerper

Hintergrund: GGTB2, Beta4Gal-T1, b4Gal-T1, Nal synthase,
Description: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose, all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose D-glucose UDP lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.

UniProt: P15291

Pathways: Glycosaminoglycan Metabolic Process