PSMC4 Antikörper (AA 368-418)

Produktnummer ABIN7454974

Produktdetails anti-PSMC4 Antikörper

Target: PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4))

Bindungsspezifität: AA 368-418

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSMC4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Verwendungszweck: Rabbit anti-PSMC4 Antibody, Affinity Purified

Homologie: Mouse,Rat,Bovine

Aufreinigung: Affinity Purified

Immunogen: Between AA 368 and 418

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:1,000 - 1:5,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PSMC4

Target: PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4))

Andere Bezeichnung: PSMC4 (PSMC4 Produkte)

Synonyme: NCU02260.1 antikoerper, AO090003000692 antikoerper, DDBDRAFT_0188209 antikoerper, DDBDRAFT_0191435 antikoerper, DDB_0188209 antikoerper, DDB_0191435 antikoerper, MIP224 antikoerper, RPT3 antikoerper, S6 antikoerper, TBP-7 antikoerper, TBP7 antikoerper, CIP21 antikoerper, Tbp7 antikoerper, 26S protease regulatory subunit 6B antikoerper, regulatory particle, ATPase-like-3 antikoerper, 26S proteasome regulatory subunit 6B antikoerper, proteasome 26S subunit, ATPase 4 antikoerper, proteasome (prosome, macropain) 26S subunit, ATPase, 4 antikoerper, LOC732870 antikoerper, rpt-3 antikoerper, ATEG_04674 antikoerper, LELG_01296 antikoerper, HCAG_00039 antikoerper, LOC5568998 antikoerper, GL50803_7950 antikoerper, EDI_044950 antikoerper, AOR_1_1218154 antikoerper, PTRG_03339 antikoerper, psmC4 antikoerper, prs6b antikoerper, LOC100381342 antikoerper, psmc4 antikoerper, PSMC4 antikoerper, Psmc4 antikoerper

Hintergrund: Background: PSMC4 [proteasome (prosome, macropain) 26S subunit, ATPase, 4] is a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSMC4 interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1 [taken from NCBI Entrez Gene (Gene ID: 5704)].

Gen-ID: 5704

NCBI Accession: NP_006494

UniProt: P43686

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway