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JMY Antikörper (AA 800-850)

JMY Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7452890
  • Target Alle JMY Antikörper anzeigen
    JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
    Bindungsspezifität
    • 8
    • 8
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 800-850
    Reaktivität
    • 44
    • 17
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 41
    • 4
    Kaninchen
    Klonalität
    • 41
    • 3
    Polyklonal
    Konjugat
    • 24
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser JMY Antikörper ist unkonjugiert
    Applikation
    • 30
    • 28
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Rabbit anti-JMY Antibody, Affinity Purified
    Aufreinigung
    Affinity Purified
    Immunogen
    between AA 800 and 850
    Isotyp
    IgG
    Top Product
    Discover our top product JMY Primärantikörper
  • Applikationshinweise

    IP: Not recommended. Use rabbit anti-JMY antibody A302-572A.

    WB: 1:2,000 - 1:10,000

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Haltbarkeit
    12 months
  • Target
    JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
    Andere Bezeichnung
    JMY (JMY Produkte)
    Synonyme
    WHDC1L3 antikoerper, junction mediating and regulatory protein, p53 cofactor antikoerper, junction-mediating and regulatory protein antikoerper, JMY antikoerper, jmy antikoerper, Jmy antikoerper
    Hintergrund
    Background: Junction-mediating and -regulatory protein (JMY) acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In the nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300 and increases p53/TP53-dependent transcription and apoptosis suggesting an important role in p53/TP53 stress response such as DNA damage. In the cytoplasm, JMY acts as a nucleation-promoting factor for both branched and un-branched actin filaments. It activates the Arp2/3 complex to induce branched actin filament networks and also catalyzes actin polymerization in the absence of Arp2/3, creating un-branched filaments [taken from the Universal Protein Resource (UniProt) Q8N9B5].
    Gen-ID
    133746
    NCBI Accession
    NP_689618
    UniProt
    Q8N9B5
    Pathways
    Regulation of Actin Filament Polymerization
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