TP53INP1 Antikörper

Produktnummer ABIN7271097

Produktdetails anti-TP53INP1 Antikörper

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TP53INP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Verwendungszweck: p53 DINP1 Rabbit mAb

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human p53 DINP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TP53INP1

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Andere Bezeichnung: TP53INP1 (TP53INP1 Produkte)

Synonyme: cb1036 antikoerper, wu:fb70a09 antikoerper, wu:fi13h08 antikoerper, zgc:158431 antikoerper, TP53INP1 antikoerper, 2700057G22Rik antikoerper, SIP antikoerper, SIP18 antikoerper, SIP27 antikoerper, Stinp antikoerper, Teap antikoerper, TP53DINP1 antikoerper, TP53INP1A antikoerper, TP53INP1B antikoerper, p53DINP1 antikoerper, Trp53inp1 antikoerper, tumor protein p53 inducible nuclear protein 1 antikoerper, tumor protein p53 inducible nuclear protein 1 S homeolog antikoerper, transformation related protein 53 inducible nuclear protein 1 antikoerper, TP53INP1 antikoerper, tp53inp1.S antikoerper, tp53inp1 antikoerper, Trp53inp1 antikoerper, Tp53inp1 antikoerper

Hintergrund: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.,SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1,Apoptosis,Autophagy,Cancer,Cell Biology & Developmental Biology,Tumor suppressors,Tumor suppressors_p53 pathway,TP53INP1

Molekulargewicht: 32kDa

Gen-ID: 94241

UniProt: Q96A56