TP53INP1 Antikörper (AA 138-205)

Produktnummer ABIN7173917

Produktdetails anti-TP53INP1 Antikörper

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Bindungsspezifität: AA 138-205

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TP53INP1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Tumor protein p53-inducible nuclear protein 1 protein (138-205AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TP53INP1

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Andere Bezeichnung: TP53INP1 (TP53INP1 Produkte)

Synonyme: cb1036 antikoerper, wu:fb70a09 antikoerper, wu:fi13h08 antikoerper, zgc:158431 antikoerper, TP53INP1 antikoerper, 2700057G22Rik antikoerper, SIP antikoerper, SIP18 antikoerper, SIP27 antikoerper, Stinp antikoerper, Teap antikoerper, TP53DINP1 antikoerper, TP53INP1A antikoerper, TP53INP1B antikoerper, p53DINP1 antikoerper, Trp53inp1 antikoerper, tumor protein p53 inducible nuclear protein 1 antikoerper, tumor protein p53 inducible nuclear protein 1 S homeolog antikoerper, transformation related protein 53 inducible nuclear protein 1 antikoerper, TP53INP1 antikoerper, tp53inp1.S antikoerper, tp53inp1 antikoerper, Trp53inp1 antikoerper, Tp53inp1 antikoerper

Hintergrund:

Background: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on \'Ser-46\' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Aliases: DKFZp434M1317 antibody, FLJ22139 antibody, p53 damage inducible nuclear protein 1 antibody, p53 dependent damage inducible nuclear protein 1 antibody, p53 inducible nuclear protein 1 antibody, p53 inducible p53DINP1 antibody, p53-dependent damage-inducible nuclear protein 1 antibody, p53DINP1 antibody, SIP antibody, Stress induced protein antibody, Stress-induced protein antibody, T53I1_HUMAN antibody, Teap antibody, TP53 DINP1 antibody, TP53 INP1 antibody, TP53DINP1 antibody, TP53INP1 antibody, TP53INP1A antibody, TP53INP1B antibody, Tumor protein p53 inducible nuclear protein 1 antibody, Tumor protein p53-inducible nuclear protein 1 antibody

UniProt: Q96A56