ARIH1 Antikörper (C-Term)

Produktnummer ABIN7265672

Produktdetails anti-ARIH1 Antikörper

Target: ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARIH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: ARIH1 Rabbit pAb

Sequenz: ARDAQERSRA ALQRYLFYCN RYMNHMQSLR FEHKLYAQVK QKMEEMQQHN MSWIEVQFLK KAVDVLCQCR ATLMYTYVFA FYLKKNNQSI IFENNQADLE NATEVLSGYL ERDISQDSLQ DIKQKVQDKY RYCESRRRVL LQHVHEGYEK DLWEYIED

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human ARIH1 (NP_005735.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ARIH1

Target: ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))

Andere Bezeichnung: ARIH1 (ARIH1 Produkte)

Synonyme: ARIH1 antikoerper, ARI-1 antikoerper, ari antikoerper, ariadne antikoerper, hari antikoerper, hhari antikoerper, ubch7bp antikoerper, ARI antikoerper, HARI antikoerper, HHARI antikoerper, UBCH7BP antikoerper, AU021774 antikoerper, Ari antikoerper, Ari1 antikoerper, Hari antikoerper, Hhari antikoerper, Ubch7bp antikoerper, Uip77 antikoerper, wu:fa18d01 antikoerper, zgc:66364 antikoerper, ariadne RBR E3 ubiquitin protein ligase 1 antikoerper, ariadne RBR E3 ubiquitin protein ligase 1 L homeolog antikoerper, ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) antikoerper, Arih1 antikoerper, ARIH1 antikoerper, arih1 antikoerper, arih1.L antikoerper

Hintergrund: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes. Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear. According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report EIF4E2 ubiquitination leads to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology.,ARIH1,ARI,HARI,HHARI,UBCH7BP,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,Endocrine & Metabolism,Amino acid metabolism,ARIH1

Gen-ID: 25820

UniProt: Q9Y4X5