ARIH1 Antikörper

Produktnummer ABIN7003436

Produktdetails anti-ARIH1 Antikörper

Target: ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARIH1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of human ARIH1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:100, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.9 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ARIH1

Target: ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))

Andere Bezeichnung: ARIH1 (ARIH1 Produkte)

Synonyme: ARIH1 antikoerper, ARI-1 antikoerper, ari antikoerper, ariadne antikoerper, hari antikoerper, hhari antikoerper, ubch7bp antikoerper, ARI antikoerper, HARI antikoerper, HHARI antikoerper, UBCH7BP antikoerper, AU021774 antikoerper, Ari antikoerper, Ari1 antikoerper, Hari antikoerper, Hhari antikoerper, Ubch7bp antikoerper, Uip77 antikoerper, wu:fa18d01 antikoerper, zgc:66364 antikoerper, ariadne RBR E3 ubiquitin protein ligase 1 antikoerper, ariadne RBR E3 ubiquitin protein ligase 1 L homeolog antikoerper, ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) antikoerper, Arih1 antikoerper, ARIH1 antikoerper, arih1 antikoerper, arih1.L antikoerper

Hintergrund: ARIH1 (ariadne homolog), also known as ubiquitin conjugating enzyme E2 binding protein 1, ARI, HARI, HHARI (human homolog of Drosophila ariadne), MOP-6 (monocyte protein 6) or UBCH7BP (UBCH7 binding protein), is a 557 amino acid cytoplasmic protein. Expressed in a wide variety of tissues, ARIH1 contains two RING-type zinc fingers and one IBR (in-between RING fingers)-type domain. ARIH1 is believed to be involved in protein degradation and protein translation. ARIH1 interacts with UBCH7 and is thought to function as an E3 ubiquitin-protein ligase (or as a component of an E3 complex) that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme (UBCH7) and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, ARIH1 interacts with and polyubiquitylates eIF4E2, thereby targeting it for proteasomal degradation.

UniProt: Q9Y4X5