Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Rekonstitution
Dilute in PBS or medium that is identical to that used in the assay system.
ABCB11 antikoerper, Bsep antikoerper, ABC16 antikoerper, BRIC2 antikoerper, BSEP antikoerper, PFIC-2 antikoerper, PFIC2 antikoerper, PGY4 antikoerper, SPGP antikoerper, Lith1 antikoerper, BSEP/SPGP antikoerper, Spgp antikoerper, ATP binding cassette subfamily B member 11 antikoerper, bile salt export pump antikoerper, ATP-binding cassette, sub-family B (MDR/TAP), member 11 antikoerper, ABCB11 antikoerper, LOC100489744 antikoerper, LOC100565276 antikoerper, EDI_111220 antikoerper, EDI_272930 antikoerper, abcb11 antikoerper, Abcb11 antikoerper
Hintergrund
Bile salt export pump,Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:16332456, PubMed:22262466, PubMed:15791618, PubMed:18985798, PubMed:19228692, PubMed:20398791, PubMed:24711118, PubMed:29507376, PubMed:20010382, PubMed:32203132). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PubMed:15901796, PubMed:18245269). {PubMed:15791618, PubMed:15901796, PubMed:16332456, PubMed:18245269, PubMed:18985798, PubMed:19228692, PubMed:20010382, PubMed:20398791, PubMed:22262466, PubMed:24711118, PubMed:29507376, PubMed:32203132}.,Bile Salt Export Pump (BSEP) is a member of the ATP-binding cassette transporters which mediate the transport of bile acid, taurocholate, and other cholate conjugates across the hepatocyte canalicular membrane into the canaliculus. BSEP is associated with progressive familial intrahepatic cholestasis type 2 (PFIC2) and benign recurrent intrahepatic cholestasis type 2 (BRIC2). PFIC2 caused by mutations in the BSEP gene appears to increase the risk of hepatocellular carcinoma in early life.,Apical cell membrane, Recycling endosome membrane, Endosome, Cell membrane,ATP-binding cassette sub-family B member 11