SERPINA4 Antikörper (AA 161-220)

Produktnummer ABIN714731

Produktdetails anti-SERPINA4 Antikörper

Target: SERPINA4 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 (SERPINA4))

Bindungsspezifität: AA 161-220

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SERPINA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus

Homologie: Human,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KLST/Kallistatin (161-220aa)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SERPINA4 Antikörper (ABIN714731)

Biswas, Maihofer, Mir, Rao, Zhang, Khandrika, Mahata, Friese, Hightower, Mahata, Baker, Nievergelt, Vaingankar, OConnor: "Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system." in: BMC medical genetics, Vol. 17, pp. 21, (2016) (PubMed).

Details zu SERPINA4

Target: SERPINA4 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 (SERPINA4))

Andere Bezeichnung: KLST (SERPINA4 Produkte)

Synonyme: KLKR antikoerper, Klk6 antikoerper, hK1 antikoerper, KAL antikoerper, KLST antikoerper, KST antikoerper, PI-4 antikoerper, PI4 antikoerper, kallistatin antikoerper, SERPINA4 antikoerper, DKFZp469E1737 antikoerper, KALps antikoerper, Klst antikoerper, kallikrein 1 antikoerper, serpin family A member 4 antikoerper, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 antikoerper, serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1 antikoerper, KLK1 antikoerper, SERPINA4 antikoerper, Serpina4 antikoerper, SPIA4 antikoerper, Serpina4-ps1 antikoerper

Hintergrund:

Synonyms: Serpin peptidase inhibitor clade A member 4, Kallikrein binding protein, Kallikrein inhibitor, Protease inhibitor 4, Serpin A4, KAL, Kallikrein binding protein, Kallikrein inhibitor, KBP, KLST, KST, MGC108582, PI4, Protease inhibitor 4, Serpin A4, Serpin peptidase inhibitor clade A member 4, SERPINA4, KAIN_HUMAN.

Background: Kallistatin is a serine proteinase inhibitor which binds to tissue kallikrein and inhibits its amidolytic and kininogenase activity. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.

Gen-ID: 5267