AATF Antikörper (N-Term)

Produktnummer ABIN7184406

Produktdetails anti-AATF Antikörper

Target: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AATF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from N-terminal of Human AATF.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu AATF

Target: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Andere Bezeichnung: AATF (AATF Produkte)

Synonyme: AATF antikoerper, ded antikoerper, che1 antikoerper, che-1 antikoerper, cb109 antikoerper, sb:cb109 antikoerper, wu:fc13d05 antikoerper, zgc:162071 antikoerper, CHE-1 antikoerper, CHE1 antikoerper, DED antikoerper, 4933415H02Rik antikoerper, 5830465M17Rik antikoerper, Che-1 antikoerper, Trb antikoerper, Ded antikoerper, apoptosis antagonizing transcription factor antikoerper, Apoptosis antagonizing transcription factor antikoerper, apoptosis antagonizing transcription factor S homeolog antikoerper, AATF antikoerper, aatf antikoerper, BFR2 antikoerper, NAEGRDRAFT_56916 antikoerper, Aatf antikoerper, aatf.S antikoerper

Hintergrund:

Background: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Lindfors K., Biochem. Biophys. Res. Commun. 276:660-666(2000).
Fanciulli M., FASEB J. 14:904-912(2000).
Di Padova M., J. Biol. Chem. 278:36496-36504(2003).

Aliases: AATF antibody, AATF_HUMAN antibody, Apoptosis antagonizing transcription factor antibody, Apoptosis-antagonizing transcription factor antibody, BFR2 antibody, CHE 1 antibody, CHE1 antibody, DED antibody, Protein AATF antibody, Rb binding protein Che 1 antibody, Rb-binding protein Che-1 antibody

UniProt: Q9NY61

Pathways: Neurotrophin Signalübertragung, SARS-CoV-2 Protein Interaktom