THO Complex 5 Antikörper

Produktnummer ABIN7184257

Produktdetails anti-THO Complex 5 Antikörper

Target: THO Complex 5 (THOC5)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THO Complex 5 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human THOC5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu THO Complex 5

Target: THO Complex 5 (THOC5)

Andere Bezeichnung: THOC5 (THOC5 Produkte)

Synonyme: C22orf19 antikoerper, Fmip antikoerper, PK1.3 antikoerper, fSAP79 antikoerper, 1700060C24Rik antikoerper, A430085L24Rik antikoerper, Sgk2 antikoerper, fc54b09 antikoerper, wu:fc54b09 antikoerper, zgc:56190 antikoerper, zgc:76912 antikoerper, THOC5 antikoerper, fmip antikoerper, thoc5 antikoerper, thoc5-a antikoerper, thoc5-b antikoerper, THO complex 5 antikoerper, THO complex 5 S homeolog antikoerper, THO complex 5 L homeolog antikoerper, THOC5 antikoerper, Thoc5 antikoerper, thoc5 antikoerper, thoc5.S antikoerper, thoc5.L antikoerper

Hintergrund:

Background: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes, probaly mediates association of the TREX and CFIm complexes. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.

Xie Y.G., Hum. Mol. Genet. 2:1361-1368(1993).
Nagase T., DNA Res. 6:63-70(1999).
Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004)

Aliases: C22orf19 antibody, Chromosome 22 open reading frame 19 antibody, Fmip antibody, Fms interacting protein antibody, fSAP79 antibody, Functional spliceosome-associated protein 79 antibody, hTREX90 antibody, KIAA0983 antibody, LOC400922 antibody, NF2/meningioma region protein pK1.3 antibody, PK1.3 antibody, Placental protein 39.2 antibody, PP39.2 antibody, THO complex 5 antibody, THO complex subunit 5 antibody, THO complex subunit 5 homolog antibody, thoc5 antibody, THOC5_HUMAN antibody

UniProt: Q13769