UBA52 Antikörper (AA 1-128) (Biotin)

Produktnummer ABIN7174410

Produktdetails anti-UBA52 Antikörper (Biotin)

Target: UBA52 (Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1 (UBA52))

Bindungsspezifität: AA 1-128

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBA52 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-60S ribosomal protein L40 protein (1-128AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu UBA52

Target: UBA52 (Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1 (UBA52))

Andere Bezeichnung: UBA52 (UBA52 Produkte)

Synonyme: CEP52 antikoerper, HUBCEP52 antikoerper, L40 antikoerper, RPL40 antikoerper, D8Ertd21e antikoerper, Gm1863 antikoerper, Rps27a antikoerper, Ubb antikoerper, Ubc antikoerper, UBCEP2 antikoerper, UB-RPL40 antikoerper, MGC80109 antikoerper, cep52 antikoerper, hubcep52 antikoerper, rpl40 antikoerper, RPS27A antikoerper, UBB antikoerper, UBC antikoerper, wu:fa91f08 antikoerper, zgc:123344 antikoerper, UBA52 antikoerper, ubiquitin A-52 residue ribosomal protein fusion product 1 antikoerper, ubiquitin A-52 residue ribosomal protein fusion product 1 L homeolog antikoerper, UBA52 antikoerper, Uba52 antikoerper, uba52.L antikoerper, uba52 antikoerper

Hintergrund:

Background: Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair, Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation, Lys-29-linked is involved in lysosomal degradation, Lys-33-linked is involved in kinase modification, Lys-48-linked is involved in protein degradation via the proteasome, Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Aliases: UBA52 antibody, UBCEP2 antibody, Ubiquitin-60S ribosomal protein L40 antibody, CEP52 antibody, Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin, 60S ribosomal protein L40 antibody, Large ribosomal subunit protein eL40)] antibody

UniProt: P62987

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, EGFR Downregulation