TRPV1 Antikörper (AA 1-155)

Produktnummer ABIN7172875

Produktdetails anti-TRPV1 Antikörper

Target: TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))

Bindungsspezifität: AA 1-155

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRPV1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Transient receptor potential cation channel subfamily V member 1 protein (1-155AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TRPV1

Target: TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))

Andere Bezeichnung: TRPV1 (TRPV1 Produkte)

Synonyme: si:dkey-9e15.2 antikoerper, VR.5'sv antikoerper, Vr1 antikoerper, Vr1l1 antikoerper, VR1 antikoerper, OTRPC1 antikoerper, TRPV1alpha antikoerper, TRPV1beta antikoerper, VR-1 antikoerper, transient receptor potential cation channel, subfamily V, member 1 antikoerper, transient receptor potential cation channel subfamily V member 1 antikoerper, trpv1 antikoerper, Trpv1 antikoerper, TRPV1 antikoerper

Hintergrund:

Background: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions ( pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.

Aliases: Capsaicin receptor antibody, DKFZp434K0220 antibody, osm 9 like TRP channel 1 antibody, Osm-9-like TRP channel 1 antibody, OTRPC1 antibody, Transient receptor potential cation channel subfamily V member 1 antibody, TRPV 1 antibody, Trpv1 antibody, TRPV1_HUMAN antibody, Vanilloid receptor 1 antibody, Vanilloid receptor subtype 1 antibody, VR 1 antibody, VR1 antibody

UniProt: Q8NER1

Pathways: Dicarboxylic Acid Transport