RAP1 Antikörper (AA 1-280)

Produktnummer ABIN7171737

Produktdetails anti-RAP1 Antikörper

Target: RAP1 (TERF2IP) (Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP))

Bindungsspezifität: AA 1-280

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAP1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Telomeric repeat-binding factor 2-interacting protein 1 protein (1-280AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RAP1

Target: RAP1 (TERF2IP) (Telomeric Repeat Binding Factor 2, Interacting Protein (TERF2IP))

Andere Bezeichnung: TERF2IP (TERF2IP Produkte)

Synonyme: DRIP5 antikoerper, RAP1 antikoerper, Rap1 antikoerper, cRAP1 antikoerper, TERF2 interacting protein antikoerper, telomeric repeat binding factor 2, interacting protein antikoerper, TERF2IP antikoerper, Terf2ip antikoerper

Hintergrund:

Background: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5\\\'-TTAGGG-3\\\' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5\\\'-TTAGGG-3\\\' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.

Aliases: Dopamine receptor interacting protein 5 antibody, Dopamine receptor-interacting protein 5 antibody, DRIP 5 antibody, DRIP5 antibody, hRap1 antibody, MGC105533 antibody, RAP 1 antibody, RAP1 homolog antibody, RAP1, yeast, homolog if antibody, RAP1, yeast, homolog of antibody, Repressor/activator protein 1 homolog antibody, TE2IP_HUMAN antibody, Telomeric Repeat Binding Factor 2 Interacting Protein antibody, Telomeric repeat-binding factor 2-interacting protein 1 antibody, TERF2-interacting protein antibody, TERF2-interacting telomeric protein 1 antibody, TERF2IP antibody, TRF2 Interacting Telomeric Protein RAP1 antibody, TRF2 interacting telomeric RAP1 protein antibody, TRF2-interacting telomeric protein 1 antibody, TRF2-interacting telomeric protein antibody

UniProt: Q9NYB0

Pathways: Zellzyklus, Telomere Maintenance