SLC5A8 Antikörper (AA 540-610)

Produktnummer ABIN7169960

Produktdetails anti-SLC5A8 Antikörper

Target: SLC5A8 (Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8))

Bindungsspezifität: AA 540-610

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC5A8 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Sodium-coupled monocarboxylate transporter 1 protein (540-610AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SLC5A8

Target: SLC5A8 (Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8))

Andere Bezeichnung: SLC5A8 (SLC5A8 Produkte)

Synonyme: Ait antikoerper, SMCT antikoerper, SMCT1 antikoerper, AIT antikoerper, RGD1564146 antikoerper, solute carrier family 5 (iodide transporter), member 8 antikoerper, solute carrier family 5 member 8 antikoerper, Slc5a8 antikoerper, SLC5A8 antikoerper

Hintergrund:

Background: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

Aliases: AIT antibody, Apical iodide transporter antibody, Electrogenic sodium monocarboxylate cotransporter antibody, MGC125354 antibody, SC5A8_HUMAN antibody, SLC5A8 antibody, SMCT antibody, SMCT1 antibody, sodium coupled monocarboxylate transporter 1 antibody, Sodium iodide related cotransporter antibody, Sodium iodide-related cotransporter antibody, Sodium-coupled monocarboxylate transporter 1 antibody, solute carrier family 5 iodide transporter member 8 antibody, Solute carrier family 5 member 8 antibody

UniProt: Q8N695