POLD2 Antikörper (AA 245-430) (FITC)

Produktnummer ABIN7150233

Produktdetails anti-POLD2 Antikörper (FITC)

Target: POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))

Bindungsspezifität: AA 245-430

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLD2 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human DNA polymerase delta subunit 2 protein (245-430AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu POLD2

Target: POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))

Andere Bezeichnung: POLD2 (POLD2 Produkte)

Synonyme: 50kDa antikoerper, p50 antikoerper, po1D2 antikoerper, cdc1 antikoerper, si:dz150f13.3 antikoerper, zgc:55633 antikoerper, zgc:77043 antikoerper, DNA polymerase delta 2, accessory subunit antikoerper, polymerase (DNA directed), delta 2, regulatory subunit antikoerper, polymerase (DNA directed), delta 2, accessory subunit L homeolog antikoerper, POLD2 antikoerper, Pold2 antikoerper, pold2.L antikoerper, pold2 antikoerper

Hintergrund:

Background: As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5\'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the POLZ complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).

Aliases: DNA polymerase delta subunit 2 antibody, DNA polymerase delta subunit p50 antibody, DNA polymerase subunit delta 2 antibody, DNA polymerase subunit delta p50 antibody, DPOD2_HUMAN antibody, POLD 2 antibody, pold2 antibody

UniProt: P49005

Pathways: Telomere Maintenance, DNA Reparatur, DNA Replication, Synthesis of DNA