NFKBIE Antikörper (pSer157)

Produktnummer ABIN710726

Produktdetails anti-NFKBIE Antikörper

Target: NFKBIE (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, epsilon (NFKBIE))

Bindungsspezifität: pSer157

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFKBIE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Cow

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human NFKBIE around the phosphorylation site of Ser157

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu NFKBIE

Target: NFKBIE (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, epsilon (NFKBIE))

Andere Bezeichnung: Ikb epsilon (NFKBIE Produkte)

Synonyme: NFKBIE antikoerper, IKBE antikoerper, Slc35b2 antikoerper, NFKB inhibitor epsilon antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon antikoerper, NFKBIE antikoerper, Nfkbie antikoerper

Hintergrund:

Synonyms: NFKBIE phospho S157, IKB epsilon Ser157, IKB epsilon S, p-IKB epsilon Ser157, p-IKB epsilon S157, I kappa B epsilon, IkappaBepsilon, IkB E, IKBE, IKB epsilon, MGC72568, NF kappa B inhibitor epsilon, NF kappa BIE, NFkappa BIE, NFkappaB inhibitor epsilon, NFKBIE, Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor epsilon, OTTHUMP00000016522, Slc35b2, solute carrier family 35, member B2.

Background: NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT, AP1 (JUN), and NFAT.

Gen-ID: 4794

Pathways: NF-kappaB Signalweg, Maintenance of Protein Location