BRE Antikörper (AA 94-383)
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- Target Alle BRE Antikörper anzeigen
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
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Bindungsspezifität
- AA 94-383
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser BRE Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human BRISC and BRCA1-A complex member 2 protein (94-383AA)
- Isotyp
- IgG
- Top Product
- Discover our top product BRE Primärantikörper
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- Applikationshinweise
- Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
- Andere Bezeichnung
- BABAM2 (BRE Produkte)
- Synonyme
- brcc4 antikoerper, brcc45 antikoerper, BRE antikoerper, LOC100231620 antikoerper, BRCC4 antikoerper, BRCC45 antikoerper, 6030405P19Rik antikoerper, AI429776 antikoerper, B830038C02Rik antikoerper, im:7141046 antikoerper, zgc:110368 antikoerper, BRISC and BRCA1 A complex member 2 antikoerper, brain and reproductive organ-expressed (TNFRSF1A modulator) antikoerper, BRISC and BRCA1 A complex member 2 L homeolog antikoerper, babam2 antikoerper, BABAM2 antikoerper, Babam2 antikoerper, BRE antikoerper, babam2.L antikoerper
- Hintergrund
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Background: Component of the BRCA1-A complex, a complex that specifically recognizes \\\'Lys-63\\\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes \\\'Lys-63\\\'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves \\\'Lys-63\\\'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1, deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect (PubMed:15465831).
Aliases: 6030405P19Rik antibody, AI429776 antibody, B830038C02Rik antibody, Brain and reproductive organ expressed (TNFRSF1A modulator) antibody, brain and reproductive organ expressed protein antibody, Brain and reproductive organ-expressed protein antibody, BRCA1 A complex subunit BRE antibody, BRCA1-A complex subunit BRE antibody, BRCA1/BRCA2 containing complex subunit 4 antibody, BRCA1/BRCA2 containing complex subunit 45 antibody, BRCA1/BRCA2-containing complex subunit 45 antibody, BRCC4 antibody, BRCC45 antibody, bre antibody, BRE_HUMAN antibody
- UniProt
- Q9NXR7
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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