ARFGEF2 Antikörper (AA 200-317) (Biotin)

Produktnummer ABIN7145777

Produktdetails anti-ARFGEF2 Antikörper (Biotin)

Target: ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))

Bindungsspezifität: AA 200-317

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARFGEF2 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 protein (200-317AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ARFGEF2

Target: ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))

Andere Bezeichnung: ARFGEF2 (ARFGEF2 Produkte)

Synonyme: AI463430 antikoerper, AW493672 antikoerper, BIG2 antikoerper, E230011G24Rik antikoerper, Big2 antikoerper, PVNH2 antikoerper, dJ1164I10.1 antikoerper, ADP ribosylation factor guanine nucleotide exchange factor 2 antikoerper, ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) antikoerper, ARFGEF2 antikoerper, Arfgef2 antikoerper

Hintergrund:

Background: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles, the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.

Aliases: ARFGEF2 antibody, ARFGEP2 antibody, BIG2Brefeldin A-inhibited guanine nucleotide-exchange protein 2 antibody, Brefeldin A-inhibited GEP 2 antibody, ADP-ribosylation factor guanine nucleotide-exchange factor 2 antibody

UniProt: Q9Y6D5