SMARCC1 Antikörper

Produktnummer ABIN7140297

Produktdetails anti-SMARCC1 Antikörper

Target: SMARCC1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 1 (SMARCC1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SMARCC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human

Aufreinigung: Affinity purified

Immunogen: Purified recombinant human BAF155 protein fragments expressed in E.coli.

Isotyp: IgG1, IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Recommended dilution:WB:1:500-1:5000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified mouse monoclonal in PBS( pH 7.4) containing with 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SMARCC1

Target: SMARCC1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 1 (SMARCC1))

Andere Bezeichnung: SMARCC1 (SMARCC1 Produkte)

Synonyme: smarcc1 antikoerper, MGC53976 antikoerper, BAF155 antikoerper, CRACC1 antikoerper, Rsc8 antikoerper, SRG3 antikoerper, SWI3 antikoerper, AI115498 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 L homeolog antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 antikoerper, smarcc1.L antikoerper, smarcc1a antikoerper, SMARCC1 antikoerper, Smarcc1 antikoerper

Hintergrund:

Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).May stimulate the ATPase activity of the catalytic subunit of the complex.Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex,a chromatin-remodeling complex recruited by vitamin D receptor (VDR),which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A,are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth by similarity.

Aliases: AI115498, BAF 155, BAF155, BRG 1 associated factor 155, BRG1 associated factor 155, BRG1-associated factor 155, Chromatin remodeling complex BAF155 subunit, CRACC 1, CRACC1, Mammalian chromatin remodeling complex BRG 1 associated factor 155,

UniProt: Q92922

Pathways: Chromatin Binding