This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This SMARCC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 963-997 amino acids from the C-terminal region of human SMARCC1.
smarcc1 antikoerper, MGC53976 antikoerper, BAF155 antikoerper, CRACC1 antikoerper, Rsc8 antikoerper, SRG3 antikoerper, SWI3 antikoerper, AI115498 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 L homeolog antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 antikoerper, smarcc1.L antikoerper, smarcc1a antikoerper, SMARCC1 antikoerper, Smarcc1 antikoerper
Hintergrund
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).