TYK2 Antikörper (pTyr1054)
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- Target Alle TYK2 Antikörper anzeigen
- TYK2 (Tyrosine Kinase 2 (TYK2))
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Bindungsspezifität
- pTyr1054
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TYK2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- Immunogen
- Peptide sequence around phosphorylation site of tyrosine 1054 (H-E-Y(p)-Y-R) derived from Human TYK2.
- Isotyp
- IgG
- Top Product
- Discover our top product TYK2 Primärantikörper
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- Applikationshinweise
- WB:1:500-1:1000,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- TYK2 (Tyrosine Kinase 2 (TYK2))
- Andere Bezeichnung
- TYK2 (TYK2 Produkte)
- Synonyme
- JTK1 antikoerper, tyrosine kinase 2 antikoerper, TYK2 antikoerper, Tyk2 antikoerper
- Hintergrund
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Background:
TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730.
Gauzzi MC, et al. (1996) J Biol Chem. 271(34): 20494-20500.Aliases: JTK 1 antibody, JTK1 antibody, Non receptor tyrosine protein kinase 2 antibody, Non receptor tyrosine protein kinase TYK2 antibody, Non-receptor tyrosine-protein kinase TYK2 antibody, OTTHUMP00000232745 antibody, OTTHUMP00000232746 antibody, OTTHUMP00000232748 antibody, Protein Tyrosine Kinase 2 antibody, TYK 2 antibody, Tyk2 antibody, TYK2_HUMAN antibody, Tyrosine kinase 2 antibody
- UniProt
- P29597
- Pathways
- JAK-STAT Signalweg, Hepatitis C
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