CAMK2D Antikörper (pThr287)

Produktnummer ABIN7138827

Produktdetails anti-CAMK2D Antikörper

Target: CAMK2D (Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D))

Bindungsspezifität: pThr287

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CAMK2D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Threonine 287(Q-E-T(p)-V-E) derived from Human CaMK2- beta/ gamma/ delta.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CAMK2D

Target: CAMK2D (Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D))

Andere Bezeichnung: CAMK2B/CAMK2G/CAMK2D (CAMK2D Produkte)

Synonyme: CAMKD antikoerper, CAMK1 antikoerper, Camk2 antikoerper, Camki antikoerper, RATCAMKI antikoerper, camk2 antikoerper, camkd antikoerper, camkII antikoerper, 2810011D23Rik antikoerper, 8030469K03Rik antikoerper, [d]-CaMKII antikoerper, mKIAA4163 antikoerper, calcium/calmodulin dependent protein kinase II delta antikoerper, calcium/calmodulin-dependent protein kinase II delta antikoerper, calcium/calmodulin dependent protein kinase (CaM kinase) II delta S homeolog antikoerper, calcium/calmodulin dependent protein kinase (CaM kinase) II delta antikoerper, calcium/calmodulin-dependent protein kinase II, delta antikoerper, CAMK2D antikoerper, Camk2d antikoerper, camk2d.S antikoerper, camk2d antikoerper

Hintergrund:

Background: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Aliases: Calcium/calmodulin dependent protein kinase (CaM kinase) II beta antibody, Calcium/calmodulin dependent protein kinase II beta antibody, Calcium/calmodulin dependent protein kinase IIB antibody, Calcium/calmodulin dependent protein kinase type II beta chain antibody, calcium/calmodulin-dependent protein kinase II beta antibody, Calcium/calmodulin-dependent protein kinase type II subunit beta antibody, CAM 2 antibody, CaM kinase II beta chain antibody, CaM kinase II beta subunit antibody, CaM kinase II subunit beta antibody, CaM-kinase II beta chain antibody, CAM2 antibody, CAMK 2 antibody, CAMK 2B antibody, CaMK II beta subunit antibody, CaMK II subunit beta antibody, CaMK-II subunit beta antibody, CAMK2 antibody, CaMK2 beta antibody, Camk2b antibody, CAMKB antibody, CaMKII beta subunit antibody, CaMKIIB antibody, KCC2B_HUMAN antibody, MGC29528 antibody, Proline rich calmodulin dependent protein kinase antibody, proline rich calmodulin-dependent protein kinase antibody

UniProt: Q13554

Pathways: WNT Signalweg, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration