AFT1 Antikörper (pSer63)

Produktnummer ABIN7138665

Produktdetails anti-AFT1 Antikörper

Target: AFT1 (Activating Transcription Factor 1 (AFT1))

Bindungsspezifität: pSer63

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AFT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 63(R-P-S(p)-Y-R) derived from Human ATF1 .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu AFT1

Target: AFT1 (Activating Transcription Factor 1 (AFT1))

Andere Bezeichnung: ATF1 (AFT1 Produkte)

Synonyme: ews-atf1 antikoerper, fus/atf-1 antikoerper, treb36 antikoerper, ATF1 antikoerper, EWS-ATF1 antikoerper, FUS/ATF-1 antikoerper, TREB36 antikoerper, Atf-1 antikoerper, wu:fc92c07 antikoerper, zgc:64099 antikoerper, activating transcription factor 1 antikoerper, activating transcription factor 1 L homeolog antikoerper, atf1 antikoerper, ATF1 antikoerper, MGC85066 antikoerper, atf1.L antikoerper, Atf1 antikoerper

Hintergrund:

Background:

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

Mackenzie KF, et al. (2013) J Immunol 190, 565-77
Dickinson RJ, et al. (2011) J Biol Chem 286, 38018-26
Wang J, Zhou JY, Wu GS (2011) J Biol Chem 286, 22384-92

Aliases: Activating transcription factor 1 antibody, ATF 1 antibody, atf1 antibody, ATF1 EWS fusion gene antibody, ATF1 FUS fusion gene antibody, ATF1_HUMAN antibody, cAMP dependent transcription factor 1 antibody, cAMP-dependent transcription factor ATF-1 antibody, Cyclic AMP dependent transcription factor ATF 1 antibody, Cyclic AMP dependent transcription factor ATF1 antibody, Cyclic AMP-dependent transcription factor ATF-1 antibody, EWS AFT1 antibody, FUS ATF 1 antibody, FUS/ATF 1 antibody, Protein TREB36 antibody, RNA binding protein activating transcription factor 1 fusion protein antibody, TREB 36 antibody, TREB36 antibody, TREB36 protein antibody

UniProt: P18846

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades