MGC75954 antikoerper, WTAP antikoerper, RGD1563824 antikoerper, wu:fi29a09 antikoerper, zgc:66202 antikoerper, 2810408K05Rik antikoerper, 9430038B09Rik antikoerper, WT1 associated protein antikoerper, Wilms tumor 1 associated protein antikoerper, wilms tumor 1 associated protein antikoerper, WT1 associated protein L homeolog antikoerper, Wilms tumour 1-associating protein antikoerper, wtap antikoerper, WTAP antikoerper, CpipJ_CPIJ006489 antikoerper, Wtap antikoerper, wtap.L antikoerper
Hintergrund
Synonyms:DKFZp686F20131, Female lethal(2)D homolog, hFL(2)D, KIAA0105, WT1 associated protein, WTAP Background:Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).