CRBN Antikörper
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- Target Alle CRBN Antikörper anzeigen
- CRBN (Cereblon (CRBN))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CRBN Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Aufreinigung
- Immunogen affinity purified
- Reinheit
- ≥95 % as determined by SDS-PAGE
- Immunogen
- cereblon
- Isotyp
- IgG
- Top Product
- Discover our top product CRBN Primärantikörper
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anti-Cereblon (CRBN) (AA 1-280) antibody
CRBN Reaktivität: Human WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Cereblon (CRBN) (AA 1-442) antibodyCRBN Reaktivität: Human WB Wirt: Maus Polyclonal unconjugated
anti-Cereblon (CRBN) (AA 35-84) antibodyCRBN Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Hamster, Affe, Schwein, Xenopus laevis WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB: 1:500-1:2000, IHC: 1:50-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Haltbarkeit
- 12 months
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- Target
- CRBN (Cereblon (CRBN))
- Andere Bezeichnung
- CRBN (CRBN Produkte)
- Synonyme
- zgc:92404 antikoerper, mrt2a antikoerper, F3N11.21 antikoerper, MRT2 antikoerper, MRT2A antikoerper, 2610203G15Rik antikoerper, 2900045O07Rik antikoerper, AF229032 antikoerper, AW108261 antikoerper, piL antikoerper, cereblon antikoerper, ATP-dependent protease La (LON) domain protein antikoerper, crbn antikoerper, CRBN antikoerper, AT2G25740 antikoerper, Crbn antikoerper
- Hintergrund
- Synonyms:cereblon, CRBN, MRT2A, Protein cereblon Background:Substrate recognition component of a DCX(DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
- Molekulargewicht
- 53 kDa
- Gen-ID
- 51185
- UniProt
- Q96SW2
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