FCGR2B Antikörper (Extracellular Domain) (FITC)

Produktnummer ABIN7077130

Produktdetails anti-FCGR2B Antikörper (FITC)

Target: FCGR2B (Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B))

Bindungsspezifität: Extracellular Domain

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FCGR2B Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Produktmerkmale: The clone 4F5, a mouse monoclonal antibody recognizes anti- FcγRIIb, a cell surface protein also known as CD32b. FcγRII has two major isoforms named FcγRIIa and FcγRIIb with high degree of homology. The clone 4F5 selectively reacts with FcγRIIb but not with FcγRIIa. The CD32b antigen is widely expressed on the cell surface of circulating B lymphocytes, monocytes, neutrophils, myeloid dendritic cells (DCs), platelets and at very low levels on plasmacytoid DCs. FcγRs (FcγRI/CD64, FcγRII/CD32, FcγRIII/CD16, and FcγRIV/CD16-2) play important roles in inflammatory cell activation, clearance, presentation of Ag, and maintenance of IgG homeostasis. Published reports claimed that 4F5 partially blocks the ligand-binding of FcRIIb and mediates an inhibitory signal by co-cross-linking FcRIIb with activating FcRs. Clone 4F5 supports study of the expression, regulation, and function of FcγRIIb and may be useful in the area of therapeutic applications where the modulation of FcγRIIb is required.

Aufreinigung: Purified

Reinheit: >95 %

Güteklasse: GMP Grade

Immunogen: Recombinant human FcgammaRIIb/c (CD32b) extracellular domain

Klon: 4F5

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu FCGR2B

Target: FCGR2B (Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B))

Andere Bezeichnung: CD32b (FCGR2B Produkte)

Synonyme: CD32 antikoerper, CD32B antikoerper, FCG2 antikoerper, FCGR2 antikoerper, IGFR2 antikoerper, FCGR2B antikoerper, AI528646 antikoerper, F630109E10Rik antikoerper, Fc[g]RII antikoerper, FcgRII antikoerper, Fcgr2 antikoerper, Fcgr2a antikoerper, Fcr-2 antikoerper, Fcr-3 antikoerper, Ly-17 antikoerper, Ly-m20 antikoerper, LyM-1 antikoerper, Lym-1 antikoerper, FCRII antikoerper, FcRII antikoerper, Fc fragment of IgG receptor IIb antikoerper, Fc fragment of IgG, low affinity IIb, receptor (CD32) antikoerper, Fc receptor, IgG, low affinity IIb antikoerper, low affinity immunoglobulin gamma Fc region receptor II antikoerper, FCGR2B antikoerper, Fcgr2b antikoerper, LOC100856270 antikoerper

Hintergrund: The clone 4F5, a mouse monoclonal antibody recognizes anti- FcγRIIb, a cell surface protein also known as CD32b. FcγRII has two major isoforms named FcγRIIa and FcγRIIb with high degree of homology. The clone 4F5 selectively reacts with FcγRIIb but not with FcγRIIa. The CD32b antigen is widely expressed on the cell surface of circulating B lymphocytes, monocytes, neutrophils, myeloid dendritic cells (DCs), platelets and at very low levels on plasmacytoid DCs. FcγRs (FcγRI/CD64, FcγRII/CD32, FcγRIII/CD16, and FcγRIV/CD16-2) play important roles in inflammatory cell activation, clearance, presentation of Ag, and maintenance of IgG homeostasis. Published reports claimed that 4F5 partially blocks the ligand-binding of FcRIIb and mediates an inhibitory signal by co-cross-linking FcRIIb with activating FcRs. Clone 4F5 supports study of the expression, regulation, and function of FcγRIIb and may be useful in the area of therapeutic applications where the modulation of FcγRIIb is required.

Gen-ID: 2213

UniProt: P31994

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, BCR Signaling